BioLLM Wiki β€Ί Disease Indications

Colorectal Cancer

These papers investigate colorectal cancer in clinical trials and cohorts involving localized and metastatic disease, as well as in HCT116 human colorectal carcinoma cells. The main questions concern neoadjuvant and immune-based treatment, metastatic disease control, biomarker-based diagnosis and prediction, and the evaluation of nanoparticle drug formulations using molecular, imaging, pharmacologic, and machine-learning methods.

Papers
2,494
Jan 2024 – Aug 2026
2024 share
2.00%
of the month's papers, on average
2025 share
2.08%
of the month's papers, on average
2026 share
2.24%
of the month's papers, on average
Change
β–² +12.0%
2024 β†’ 2026, relative

Share of papers by month

Peak 2.54% in May 2026. Month-by-month values and sub-terms are on Keyword Trends.

Jan 2024Aug 2026

Immunotherapy and organ preservation

Neoadjuvant immune treatment is being evaluated in deficient-mismatch-repair colon cancer and in organ-preserving strategies: a phase II trial tested a single cycle of pembrolizumab before surgery, while a case report used watch-and-wait after clinical complete response following five sessions of neoadjuvant immunotherapy (PMIDs 39692004, 39430753). Studies of mismatch-repair-proficient or microsatellite-stable disease tested durvalumab with olaparib or cediranib and pembrolizumab with capecitabine and bevacizumab, with tumor immune changes, response, survival, and safety as endpoints (PMIDs 38960798, 41826077). Preclinical approaches used a probiotic mixture to suppress STAT3 and induce p53-associated apoptosis in the AOM/DSS model, and a selenium nanoparticle–extracellular-vesicle/probiotic complex with IL-32 to enhance CD8+ T-cell responses in humanized xenografts (PMIDs 39641861, 40081224).

πŸ“„ Annals of surgery β†—πŸ“„ Frontiers in immunology β†—πŸ“„ Clinical colorectal cancer β†—πŸ“„ Clinical colorectal cancer β†—πŸ“„ Probiotics and antimicrobial proteins β†—πŸ“„ Biomaterials β†—

Biomarkers and prediction

Diagnostic and prognostic studies use circulating molecules, tumor databases, and imaging-derived features to classify colorectal cancer and its behavior. A serum microRNA panel was developed in a training cohort and evaluated in validation and blinded cohorts, while a SEER-based machine-learning model predicted liver and/or lung metastasis and was tested in an independent Chinese hospital cohort (PMIDs 39244686, 38704899). MRI-based models were developed to estimate microsatellite-instability status, predict pathological downstaging after neoadjuvant chemoradiotherapy, and noninvasively predict tertiary lymphoid structures together with immunotherapy response and prognosis in rectal cancer (PMIDs 40016002, 41100929, 41499583).

πŸ“„ International journal of cancer β†—πŸ“„ European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology β†—πŸ“„ Academic radiology β†—πŸ“„ International journal of medical informatics β†—πŸ“„ International journal of surgery (London, England) β†—

Targeted delivery and drug discovery

Several studies developed carrier systems for colon cancer applications: l-carnitine-modified pectin–chitosan nanoparticles loaded inositol hexaphosphate and showed uptake and cytotoxicity in colon cancer cell lines, chitosan-modified gellan-gum nanoparticles were developed to modulate bevacizumab mucoadhesion and permeability, piperine was encapsulated in PLGA-b-PEG nanoparticles and evaluated in HCT116 cells, and magnetic cobalt-ferrite/chitosan-bilirubin nanoparticles delivered doxorubicin and reduced tumor size in an in vivo CT26 colon cancer model, particularly with magnetic guidance (PMIDs 38423444, 38373560, 40553907, 39756160). Small-molecule programs include LP46, a selective IKKΞ² inhibitor that attenuated NF-ΞΊB signaling and suppressed viability and proliferation in HCT116 cells, while suppressing tumor growth in RKO and MC38 xenograft models and an MC38 syngeneic model, and compound 6, a dual Aurora/HDAC inhibitor that induced G2/M arrest and reduced growth in HCT-116 xenografts (PMIDs 41327756, 41213111). Other targeted strategies include the VHL-dependent PROTAC CH091138, which selectively degraded KRASG12D, suppressed the growth of KRASG12D-harboring patient-derived organoids, and reduced tumor growth in an AsPC-1 xenograft model, and screening of new Pt(II) complexes that identified compounds with activity against oxaliplatin-resistant colon cancer cells (PMIDs 40651134, 38845105).

πŸ“„ International journal of biological macromolecules β†—πŸ“„ International journal of biological macromolecules β†—πŸ“„ European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V β†—πŸ“„ Colloids and surfaces. B, Biointerfaces β†—πŸ“„ Journal of medicinal chemistry β†—πŸ“„ Journal of medicinal chemistry β†—πŸ“„ European journal of medicinal chemistry β†—πŸ“„ Journal of medicinal chemistry β†—

Metastatic disease management

Clinical studies examine locoregional treatment for colorectal liver or peritoneal metastases, including a pretransplant protocol combining systemic chemotherapy with intensive locoregional therapy and selection by positron-emission tomography and carcinoembryonic-antigen measurements; nine of 27 evaluated patients proceeded to liver transplantation (PMID 38833301). Hepatic arterial infusion of oxaliplatin/5-fluorouracil or irinotecan/5-fluorouracil with intravenous bevacizumab and leucovorin was retrospectively assessed in unresectable liver metastases refractory to standard chemotherapy, while a multimodal case combined FOLFOX, bevacizumab, bowel and liver resection, stereotactic ablative radiotherapy, and multiparametric magnetic resonance imaging (PMIDs 41196875, 40568773). For peritoneal dissemination, studies evaluate cytoreductive surgery with hyperthermic intraperitoneal chemotherapy across mucinous and non-mucinous tumors and characterize systemic oxaliplatin exposure after electrostatic pressurized intraperitoneal aerosol chemotherapy (PMIDs 40990113, 41580538).

πŸ“„ Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society β†—πŸ“„ PloS one β†—πŸ“„ Annals of the Royal College of Surgeons of England β†—πŸ“„ The American surgeon β†—πŸ“„ Annals of surgical oncology β†—

Written by gpt-5.6-luna from 96 of this keyword's papers, a few from every whole month through Aug 2026; every paragraph was checked against the abstracts it cites. A paper counts for the keyword when its title, abstract, keywords or MeSH headings match the keyword's terms. Not medical advice; see the Disclaimer.