📚BioLLM Wiki

The papers examine prognosis and outcomes in bladder cancer, metastatic hormone-sensitive prostate cancer, advanced hepatocellular carcinoma, cardiovascular disease, advanced chronic liver disease, and extremely preterm infants.

The papers investigate biomarkers and molecular profiles for diagnosis, prognosis, treatment response, and disease differentiation across bladder, pancreatic, B-cell, and prostate cancers; Alzheimer’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia; and major depressive and bipolar disorders.

These papers apply machine learning and artificial intelligence to single-cell RNA-sequencing, small-molecule, pathology image and language, and electronic health record data for prognostic modeling, disease and toxicity prediction, risk assessment, pathology question answering, and clinical documentation.

These papers examine quality of life and related outcomes across type 1 diabetes, ovarian cancer, multiple sclerosis, obstructive sleep apnea, and spinal cord injury.

These studies investigate liposomes, polymeric nanoparticles, lipid nanoparticles, nanoemulsions, hydrogel microspheres, and manganese ferrite nanoparticles for delivering doxorubicin, inositol hexaphosphate, mRNA, and vaccine antigens, as well as for glioma MRI.

The papers investigate drug-delivery systems designed to enhance oral drug absorption, pulmonary mucus penetration, cellular or tumor targeting, and sustained or responsive release through oral, ocular, pulmonary, transdermal, intravitreal, and intratracheal administration.

These papers investigate hydrogel-based wound dressings and delivery systems for diabetic and cutaneous wounds, including approaches addressing inflammation, oxidative stress, exudation, and scar formation.

Research on antimicrobial strategies in these papers spans antibiotic-resistance surveillance and treatment optimization, development of antimicrobial peptides using machine learning and de novo design, β-lactamase-inhibitor combinations, cranberry-functionalized hydrogels, and phage-inspired nanocarrier delivery systems.

These papers examine stroke and cardiovascular disease in atrial fibrillation, ischemic stroke, heart failure, diabetes, atherosclerosis, and vascular aging.

The papers study breast cancer, including hormone-receptor-defined HER2-negative disease and triple-negative breast cancer, as well as metastatic and advanced breast cancer.

These papers examine non-small cell and small cell lung cancer, focusing on resistance to osimertinib or PARP inhibitors, immune responses to neoadjuvant immunotherapy, molecular biomarkers, spread through air spaces, and treatment planning or prediction of treatment outcomes.

These papers investigate colorectal cancer in clinical trials and cohorts involving localized and metastatic disease, as well as in HCT116 human colorectal carcinoma cells.

The papers investigate immunotherapy and biomarkers across bladder cancer, lung adenocarcinoma, pancreatic ductal adenocarcinoma, metastatic non-small-cell lung cancer, nasopharyngeal carcinoma, and esophageal squamous cell carcinoma.

The papers use apoptosis as a mechanistic endpoint in studies of cancer treatment, drug resistance, tissue injury, and metabolic disease.

These papers examine ferroptosis as an iron-dependent, lipid-peroxidation-related cell-death process in cancer, diabetic nephropathy, renal aging, cerebral ischemic injury, and retinal degeneration.

These papers examine type 2 diabetes through glucose-lowering treatment with tirzepatide, dietary management supported by a cloud-based data platform, genetic heterogeneity, and mechanisms involved in diabetic nephropathy and diabetic cardiomyopathy.

The papers examine associations of obesity and metabolic health with cancer, COVID-19 severity and mortality, progression from prediabetes to diabetes among people with HIV, pediatric dyspnea, and idiopathic intracranial hypertension, using cohort analyses, administrative claims data, a federated research database, phase 1 randomized studies, and retrospective medical records.

These papers use molecular docking to screen or investigate compounds against targets including PI3Kalpha in gastric cancer, PDE5A/PDE6A, glioma-associated proteins, SARS-CoV-2 Mpro, and Mycobacterium tuberculosis DNA gyrase.

These papers examine kinase inhibitors as treatments and experimental approaches across solid cancers, hematologic malignancies, necrobiosis lipoidica, and bone-resorption disease.