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Hydrogel & Wound Healing

These papers investigate hydrogel-based wound dressings and delivery systems for diabetic and cutaneous wounds, including approaches addressing inflammation, oxidative stress, exudation, and scar formation. The studies combine natural or synthetic polymer-based hydrogels with exosomes, growth factors, antimicrobial or antioxidant components, and nanoparticles, including systems designed for sustained or stage-specific release. They evaluate these materials using cell assays and mouse or rat wound models. Reported outcomes include antibiofilm or antibacterial activity, reduced oxidative and inflammatory responses, increased fibroblast proliferation or migration and angiogenesis, improved wound closure and collagen remodeling, and reduced scar formation.

Papers
6,011
Jan 2024 – Aug 2026
2024 share
4.94%
of the month's papers, on average
2025 share
5.36%
of the month's papers, on average
2026 share
4.93%
of the month's papers, on average
Change
▼ -0.2%
2024 → 2026, relative

Share of papers by month

Peak 6.29% in Sep 2025. Month-by-month values and sub-terms are on Keyword Trends.

Jan 2024Aug 2026

Multifunctional diabetic-wound dressings

Several multifunctional hydrogels were developed for diabetic wound healing, addressing biofilm infection, oxidative stress, inflammation, excessive exudation, and angiogenesis. A PVA/chitosan hydrogel containing graphene oxide–cranberry nanohybrids was stretchable, self-healing, antioxidant, electroconductive, and antibiofilm, while a bilayer polysaccharide hydrogel containing quaternized chitosan and L-arginine-modified polyoxometalates bound to dynamic tissue surfaces, formed a protective barrier, and exhibited antibacterial activity (PMIDs 39651355, 39048233). In laboratory studies, GelMA containing gallic acid and DMOG-loaded ginseng-derived nanoparticles inhibited iNOS production in mouse immune cells and promoted fibroblast and endothelial-cell growth and migration and endothelial tube formation. In a type 1 diabetic rat wound model, it attenuated inflammation, promoted collagen-fiber and blood-vessel formation, and accelerated healing. A PGS/PLA hydrogel combined with hyperbaric oxygen improved wound closure, fibroblast density, vascular density, collagen deposition, oxidative-stress biomarkers, and tensile strength in diabetic rats (PMIDs 38914387, 40896868).

📄 International journal of nanomedicine ↗📄 Carbohydrate polymers ↗📄 International journal of biological macromolecules ↗📄 Tissue & cell ↗

Exosome and growth-factor delivery

Hydrogels can provide sustained release of extracellular vesicles that otherwise undergo rapid clearance in vivo. A recombinant human collagen I/carboxymethyl chitosan hydrogel sustained release of exosomes derived from human umbilical cord mesenchymal stem cells, while a lyophilizable hyaluronic-acid macroporous hydrogel encapsulated the same type of exosomes with antimicrobial peptide DP7 and promoted tissue regeneration while inhibiting scar formation in a mouse model of deep second-degree burn infection healing (PMIDs 38484819, 38581764). Quercetin-pretreated mesenchymal-stem-cell exosomes enhanced fibroblast proliferation and migration and improved diabetic wound healing in rats while altering gut microbiota and metabolic profiles, and fibrin hydrogel microspheres releasing VEGF and bFGF increased fibroblast proliferation, neovascularization, collagen deposition, and wound tensile strength in streptozotocin-induced diabetic rats (PMIDs 39619055, 41478021).

📄 International journal of biological macromolecules ↗📄 Biomaterials ↗📄 International journal of nanomedicine ↗📄 Tissue & cell ↗

Responsive and electroactive systems

Some wound platforms respond to environmental pH or external stimulation. An injectable PF-127 hydrogel loaded with eriodictyol provided sustained release, stopped bleeding, reduced local oxidative-stress damage and inflammatory-factor expression, promoted fibroblast migration, and inhibited excessive collagen deposition. A thermally stable chitosan scaffold captured exosomes from human umbilical-cord mesenchymal stem cells in acidic conditions and released them in neutral or alkaline environments (PMIDs 40157113, 40024417). Other dressings use photodynamic or electrical effects: ginger-derived carbon quantum dots in a PVA/chitosan film generated ROS under light irradiation and inactivated S. aureus, while an ultrasound-triggered piezoelectric film combined with a conductive chitosan-derived hydrogel to inhibit fibroblast proliferation and modulate collagen deposition, thereby reducing scar formation (PMIDs 40043980, 41116501).

📄 Biomaterials advances ↗📄 International journal of biological macromolecules ↗📄 International journal of biological macromolecules ↗📄 Carbohydrate polymers ↗

Antimicrobial natural-product dressings

Copper nanoparticles produced and stabilized in a sodium lignosulfonate–starch mixed hydrogel averaged 5–10 nm and were applied to induced burn wounds in Wistar rats. Deep-eutectic-solvent formulations improved the solubilization and aqueous dispersity of essential oils, and a clove-oil formulation promoted healing of methicillin-resistant Staphylococcus aureus-infected wounds in vivo (PMIDs 39098681, 39480745). A Janus polyvinyl alcohol/collagen membrane incorporated Orthosiphon aristatus extract and dimethyloxalylglycine; its dense outer layer acted as a physical shield, while its porous hydrophilic inner layer absorbed exudates and supported cells. In diabetic rats, the membrane accelerated wound closure and increased collagen deposition (PMID 42132851).

📄 International journal of biological macromolecules ↗📄 Langmuir : the ACS journal of surfaces and colloids ↗📄 Biomaterials science ↗

Written by gpt-5.6-luna from 96 of this keyword's papers, a few from every whole month through Aug 2026; every paragraph was checked against the abstracts it cites. A paper counts for the keyword when its title, abstract, keywords or MeSH headings match the keyword's terms. Not medical advice; see the Disclaimer.