Dynamic thromboembolic risk
Several studies refine prediction of ischemic stroke and bleeding in atrial fibrillation. Recalculated CHA2DS2-VASc and HAS-BLED scores during six years of vitamin K antagonist treatment improved outcome assessment compared with baseline scores, while a landmarking model used time-dependent variables and Fine-Gray competing-risk methods to dynamically predict thromboembolism and bleeding in patients receiving direct oral anticoagulants (38460882; 41147381). In patients undergoing mitral valve transcatheter edge-to-edge repair, direct oral anticoagulants and vitamin K antagonists were compared using a composite of ischemic cerebrovascular and bleeding events (39895535).
📄 Revista espanola de cardiologia (English ed.) ↗📄 Journal of the American Heart Association ↗📄 Journal of the American Heart Association ↗
Stroke treatment and recovery
The stroke-focused papers evaluate secondary prevention, acute ischemic stroke treatment, and neurological recovery. An outpatient study assessed adherence to antihypertensives, antiplatelets, and statins after ischemic stroke, whereas a real-world study evaluated evolocumab on a background of statin therapy during the acute phase of ischemic stroke using lipid target attainment and major adverse cardiovascular events (38218048; 38063944). Mechanical thrombectomy was described in a vertebrobasilar occlusion case with bilateral sensorineural hearing loss, and deferoxamine was examined for early neurological improvement after intracerebral hemorrhage using serial NIH Stroke Scale measurements (39644154; 40418029).
📄 Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association ↗📄 Journal of thrombosis and thrombolysis ↗📄 The neuroradiology journal ↗📄 International journal of stroke : official journal of the International Stroke Society ↗
Heart failure risk and treatment
Heart-failure studies address prognosis, body size, treatment implementation, and therapeutic selection. In acute heart failure, beta-blocker use was evaluated in relation to NT-proBNP and mortality, while cohorts of patients eligible for cardiac resynchronization therapy and patients with acute HFpEF or HFrEF examined BMI in relation to mortality and other outcomes (39015043; 39031161; 40012479). The SwedeHF registry assessed use of renin-angiotensin system inhibitors or angiotensin receptor-neprilysin inhibitors, beta-blockers, mineralocorticoid receptor antagonists, and SGLT2 inhibitors during the first year after HFrEF diagnosis, and a cost-effectiveness analysis compared ACE inhibitors with ARBs (39783801; 39252272).
📄 ESC heart failure ↗📄 ESC heart failure ↗📄 Minerva cardiology and angiology ↗📄 European journal of heart failure ↗📄 Medicine ↗
Diabetes and atherosclerotic disease
These papers connect glycemic regulation, insulin resistance, lipid handling, and cardiovascular outcomes. In diabetic ApoE-deficient mice, liraglutide and ipragliflozin were tested separately and together for effects on atherosclerotic lesions, while a Hong Kong cohort examined whether initiating a DPP-4 inhibitor below versus above an HbA1c threshold affected HbA1c variability and major clinical events (38626913; 38802991). The ARIC analysis evaluated triglyceride-glucose-derived indices as predictors of cardiometabolic multimorbidity comprising diabetes, stroke, and coronary heart disease, and a prospective study assessed left-ventricular diastolic dysfunction in normotensive patients with type 2 diabetes (41468367; 40452345). In macrophage experiments, dapagliflozin combined with alirocumab reduced CD36-associated lipid-droplet formation and altered lipoprotein lipase activity more than either treatment alone (40990667).
📄 Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association ↗📄 Diabetes, obesity & metabolism ↗📄 PloS one ↗📄 Annals of African medicine ↗📄 International journal of surgery (London, England) ↗
Vascular biomarkers and imaging
Studies examined measures and models related to vascular injury, cardiovascular risk, and ischemic stroke. Aortic stiffness in the Rotterdam Study was analyzed as a predictor of coronary heart disease, stroke, cardiovascular disease, and mortality across age and sex groups, while post-COVID-19 research measured endothelial-colony forming cells and angiogenesis-related proteins at six and twelve months after infection (39196691; 38324145). A ceramide-based CER24 score was evaluated against the CERT1 score for predicting a composite outcome of all-cause mortality or nonfatal myocardial infarction in patients with suspected or known coronary artery disease (40685265). For acute ischemic stroke imaging, a symmetry-based segmentation method integrating 2.5D ResUNet and 3D nnUNet was developed to segment ischemic lesions on non-contrast CT scans (40908314).
📄 Journal of hypertension ↗📄 Infection ↗📄 Nutrition, metabolism, and cardiovascular diseases : NMCD ↗📄 Clinical neuroradiology ↗